Cabo San Lucas, commonly called Cabo in American English, is a city at the southern tip of the Baja California Peninsula, in the Mexican state of Baja California Sur. Cabo San Lucas together with San José del Cabo is known as Los Cabos. Cabo is a varied destination that captures the essence of Baja Peninsula in its many resorts, championship golf courses, world-class dining and amazing outdoor activities. The city also houses a range of wildlife including rays, sharks, birds like eagles and a range of fish like mahi-mahi (dorado) and stripe marlin. For much of its history, Cabo was a sleepy, remote fishing port which was generally accessed either by ship or a three-hour drive from La Paz. In 1977, the airport to the north of San Jose del Cabo was expanded to handle jet aircraft and international flights, thereby launching the transformation of Cabo into one of the most popular resort destinations in Mexico.

San Francisco, officially the City and County of San Francisco, is the financial, cultural, and transportation center of the San Francisco Bay Area, a region of 7.5 million people which includes San Jose and Oakland. The only consolidated city-county in California, it encompasses a land area of about 46.9 square miles (121 km2) on the northern end of the San Francisco Peninsula, giving it a density of about 17,179 people per square mile (6,632 people per km2). It is the most densely settled large city (population greater than 200,000) in the state of California and the second-most densely populated large city in the United States after New York City. San Francisco is the fourth most populous city in California and the 13th most populous city in the United States, with a population of 805,235 as of the 2010 Census. The San Francisco-Oakland-Fremont metropolitan area has a population of 4,335,391.

San Diego, named after Saint Didacus, is the eighth-largest city in the United States and second-largest city in California after Los Angeles, with a population of 1,306,300 (Jul 2009) within its administrative limits on a land area of 372.1 square miles (963.7 km2). The city is located on the coast of the Pacific Ocean in Southern California. The urban area of San Diego extends beyond the administrative city limits with a population of 2,880,000. San Diego is also the county seat of San Diego County, the 5th largest county, by population, in the United States.   

Key West is an island in the Straits of Florida on the North American continent at the southernmost tip of the Florida Keys. It is considered the southernmost city in the continental United States. The city also occupies nearby islands and portions of nearby islands. It’s popularly known for its stunning beaches, coral reefs – destinations for diving and snorkeling.

Miami is a major city located on the Atlantic coast in southeastern Florida and the county seat of Miami-Dade County, the most populous county in Florida and the eighth-most populous county in the United States with a population of 2,500,625. The 42nd largest city in the United States, with a population of 433,136, it is the principal, central, and most populous city of the South {Florida} metropolitan area, the most populous metropolis in the Southeastern United States. According to the US Census Bureau, Miami's metro area is the seventh most populous in the United States, with an estimated population of 5,547,051 in 2009. 

Acapulco (officially known as Acapulco de Juárez) is a resort city in the state of Guerrero on the Pacific coast of Mexico. It is located on a deep, semi-circular bay and has been a port since the early colonial period of Mexico's history. It is a port of call for shipping and cruising lines running between Panama and San Francisco, California, United States. The city of Acapulco is the largest in the state, far larger than the state capital Chilpancingo. Acapulco is also Mexico's largest beach and balneario resorted city. The city is best known as one of Mexico's oldest and most well-known beach resorts, which came into prominence in the 1950s as a getaway for Hollywood stars and millionaires. Acapulco is still famous for its nightlife and still attracts many vacationers, although most are now from Mexico itself. The resort area is divided into two: The north end of the bay is the "traditional" area, where the famous in the mid-20th century vacationed; and the south end is dominated by newer luxury high-rise hotels.

Cartagena is Colombia's most famous tourist destination on the Caribbean coast. The city is renowned for its colonial and colourful architecture. With a tropical climate, the city is also a popular beach destination. The city was founded on June 1, 1533, and named after Cartagena, Spain, itself after the original Carthage in Tunisia. However, settlement in this region around Cartagena Bay by various indigenous people dates back to 4000 BC. During the colonial period Cartagena served a key role in administration and expansion of the Spanish empire. It was a center of political and economic activity due to the presence of royalty and wealthy viceroys. In 1984 Cartagena's colonial walled city and fortress were designated a UNESCO World Heritage Site.